Comparative Genome Analysis of Four Elephant Endotheliotropic 4 Herpesviruses EEHV 3 , EEHV 4 , EEHV 5 and EEHV 6 from Cases of 5 Hemorrhagic
نویسندگان
چکیده
7 Jian-Chao Zong, Erin M. Latimer, Simon Y. Long, Laura K. Richman, Sarah Y. Heaggans 8 and 9 Gary S. Hayward 10 11 12 (1) Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School of 13 Medicine, Baltimore, Maryland and 14 (2) National Elephant Herpesvirus Laboratory, Pathology Department, Smithsonian’s National Zoo, 15 Washington, DC. 16 17 Running Title: Genome Analysis of New Hemorrhagic Probosciviruses. 18 [Word count Abstract = 249. Main text 10,982] 19 # = Corresponding Author: [email protected] 20
منابع مشابه
Identification of shedders of elephant endotheliotropic herpesviruses among Asian elephants (Elephas maximus) in Switzerland
Elephants, particularly Asian (Elephas maximus), are threatened by lethal elephant hemorrhagic disease (EHD) due to elephant endotheliotropic herpesviruses (EEHV). At least five of seven known EEHV types have been associated to EHD, with types 1, 4, and 5 predominantly affecting Asian elephants. In Switzerland, at least three Asian elephants have been lost due to EHD but nothing is known about ...
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6 Laura K. Richman , Jian-Chao Zong , Erin M. Latimer 2 , Justin Lock , Robert 7 Fleischer , Sarah Y. Heaggans 1 and Gary S. Hayward 1# 8 9 10 (1) Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins School 11 of Medicine, Baltimore, Maryland 12 and 13 (2) National Elephant Herpesvirus Laboratory, Pathology Department, and (3) Center for Conservation Ecology ...
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Elephant Endotheliotropic Herpesvirus (EEHV) can cause lethal hemorrhagic disease in juvenile Asian elephants, an endangered species. One hypothesis to explain this vulnerability of some juvenile elephants is that they fail to mount an effective T cell response to the virus. To our knowledge, there have been no studies of Asian elephant T cell responses to EEHV. To address this deficiency, we v...
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BACKGROUND Elephants are classified as critically endangered animals by the International Union for Conservation of Species (IUCN). Elephant endotheliotropic herpesvirus (EEHV) poses a large threat to breeding programs of captive Asian elephants by causing fatal haemorrhagic disease. EEHV infection is detected by PCR in samples from both clinically ill and asymptomatic elephants with an active ...
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